Abstract
Confocal microscopy is a modern imaging device that has been extensively applied in skin oncology. More specifically, for tumor margin assessment, it has been used in two modalities: reflectance mode (in vivo on skin patient) and fluorescence mode (on freshly excised specimen). Although in vivo reflectance confocal microscopy is an add-on tool for lentigo maligna mapping, fluorescence confocal microscopy is far superior for basal cell carcinoma and squamous cell carcinoma margin assessment in the Mohs setting. This article provides a comprehensive overview of the use of confocal microscopy for skin cancer margin evaluation.
🔬 Techniques
✨ Fluorophores
🧪 Sample Preparation
🔬 Cell Lines
🏭 Microscope Brands
🏛️ Research Organizations (ROR)
Affiliated research institutions:
📊 Figures
Fig. 1
( A ) Tumor silhouette of BCC was highlighted by higher fluorescence signal ( dashed line; scale bar, 750 u03bcm). ( B ) Nodular BCC on frozen section revealing an excellent correlation with FCM image...
Fig. 2
( A ) Low-resolution FCM image showing a BCC tumoral proliferation ( arrows ; scale bar, 750 u03bcm). ( B ) Stained section depicted an excellent correlation with FCM image ( arrows ) in A (hematoxyli...
Fig. 3
( A ) Highly fluorescent basaloid tumor islands sharply demarcated compared with background dermis (scale bar, 750 u03bcm) and ( B ) their histologic correlates (hematoxylin-eosin, original magnificat...
Fig. 4
( A ) FCM mosaic reveals a well-defined cutaneous squamous cell carcinoma silhouette with sharp demarcation and highly fluorescent areas (scale bar, 750 u03bcm). ( B ) Corresponding histopathologic im...
Figure images are served from the NIH/NLM PubMed Central Open Access Subset or Europe PMC; copyright remains with the publishers and authors.
💬 Discussion
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