Abstract
Genetically encoded optical actuators and indicators have changed the landscape of neuroscience, enabling targetable control and readout of specific components of intact neural circuits in behaving animals. Here, we review the development of optical neural interfaces, focusing on hardware designed for optical control of neural activity, integrated optical control and electrical readout, and optical readout of population and single-cell neural activity in freely moving mammals.
🔬 Techniques
✨ Fluorophores
🧪 Sample Preparation
🔬 Cell Lines
🏭 Microscope Brands
📷 Detectors
🏛️ Research Organizations (ROR)
Affiliated research institutions:
📊 Figures
Figure 1
Optogenetics for control of genetically or topologically defined neural subtypes. ( a ) Electrical stimulation can be effective for modulating local neural activity, but the heterogeneity of brain tis...
Figure 2
Optical-neural interfaces for light delivery to brain tissue in freely moving mammals. ( a ) The original fiberoptic neural interface ( 27a ), in this case implemented via a cannula implanted over the...
Figure 3
Integrated neurophysiology and optical control. ( a ) Optical fibers can be incorporated into multisite silicon probe designs suitable for use in freely behaving rats. (Panel modified with permission ...
Figure 4
Optical-neural interfaces for readout of neural signals. Several approaches have been developed for optically monitoring neural signals in freely behaving mammals. ( a ) Fiber-based bulk tissue optica...
Figure images are served from the NIH/NLM PubMed Central Open Access Subset or Europe PMC; copyright remains with the publishers and authors.
💬 Discussion
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