Technique • 1512 papers
Synergistic advances in fluorescent protein engineering and live-cell imaging techniques in recent years have fueled the concurrent development and application of genetically encoded fluorescent reporters...
The neural basis of abnormal social behavior in autism spectrum disorders (ASDs) remains incompletely understood. Here we used two complementary but independent brain-wide mapping approaches,...
AbstractPhotoreceptor chromophore, 11-cis retinal (11CR) and the photoproduct, all-trans retinal (ATR), are present in the retina at higher concentrations and interact with the visual cells....
Macroautophagy is essential for the long-term health of neurons and astrocytes in the central nervous system (CNS). The six mammalian ATG8 paralogs (LC3A/B/C and GABARAP/GABARAPL1/L2)...
Voltage dynamics in dendrites, which result both from integrating synaptic inputs and back-propagating action potentials (bAPs) from the soma, contribute to plasticity. Mapping these dynamics...
Abstract An animal’s survival hinges on its ability to integrate past information to modify future behavior. The nematode C. elegans adapts its behavior based on...
Abstract Cortical processing is believed to involve the selective amplification of specific inputs by recurrent networks. But whether selective amplification operates within the millimeter-scale networks...
The translation of mRNA is a tightly regulated, energy-intensive process that drives cellular diversity. Understanding its control requires tools that can capture behavior across scales....
ABCA4-associated retinopathies (Stargardt disease) are the most common inherited macular dystrophy and a leading cause of early onset central vision loss. Biallelic pathogenic variants in...
ABSTRACT Dynamic FGF/ERK signaling plays key roles in development, regeneration, and disease. We recently developed a zebrafish-optimized optogenetic tool, bOpto-FGF, that enables reversible activation of...