Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in humans in almost every country, causing the disease COVID-19. Since the start of the COVID-19 pandemic, research efforts have been strongly directed towards obtaining a full understanding of the biology of the viral infection, in order to develop a vaccine and therapeutic approaches. In particular, structural studies have allowed to comprehend the molecular basis underlying the role of many of the SARS-CoV-2 proteins, and to make rapid progress towards treatment and preventive therapeutics. Despite the great advances that have been provided by these studies, many knowledge gaps on the biology and molecular basis of SARS-CoV-2 infection still remain. Filling these gaps will be the key to tackle this pandemic, through development of effective treatments and specific vaccination strategies.
🔬 Techniques
🔭 Microscopes
✨ Fluorophores
🧪 Sample Preparation
🔬 Cell Lines
💾 Data Repositories
🏛️ Research Organizations (ROR)
Affiliated research institutions:
📊 Figures
FIGURE 1
Known structures for SARS-CoV-2 proteins. (A) Schematic representation of genomic organization of SARS-CoV-2. Structural proteins are shown in pale blue, non-structural proteins are shown in green and...
FIGURE 2
Different conformations of the SARS-CoV-2 spike protein S. Schematic representation of the stages of SARS-CoV-2 fusion to host cells membrane. The S trimer is exposed on the envelope of assembled viru...
FIGURE 3
The SARS-CoV-2 replication-transcription complex. (A) Schematic representation of the non-structural proteins that were reported to intervene during the distinct steps of viral RNA replication. Endopl...
Figure images are served from the NIH/NLM PubMed Central Open Access Subset or Europe PMC; copyright remains with the publishers and authors.
💬 Discussion
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