Biophysical isolation and identification of circulating tumor cells.
Isolation and enumeration of circulating tumor cells (CTCs) from blood is important for determining patient prognosis and monitoring treatment. Methods based on affinity to cell...
Immunofluorescence Microscopy
Immunofluorescence Microscopy
Technique • 4748 papers
Therapeutic efficacy of different routes of mesenchymal stem cell administration in corneal injury.
PURPOSE: Corneal injuries are associated with significant impairment in vision. Mesenchymal stem cells (MSCs) have been shown to limit inflammation and promote tissue repair at...
GAS2-like proteins mediate communication between microtubules and actin through interactions with end-binding proteins.
Crosstalk between the microtubule (MT) and actin cytoskeletons is fundamental to many cellular processes including cell polarisation and cell motility. Previous work has shown that...
The VEGFR2 receptor tyrosine kinase undergoes constitutive endosome-to-plasma membrane recycling.
The VEGFR2 receptor tyrosine kinase regulates vascular physiology and animal development. The mechanism underlying VEGFR2 membrane trafficking is not well understood. Herein, we show that...
Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution.
Abstract The speed of high-resolution optical imaging has been a rate-limiting factor for meso-scale mapping of brain structures and functional circuits, which is of fundamental...
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COPI selectively drives maturation of the early Golgi.
COPI coated vesicles carry material between Golgi compartments, but the role of COPI in the secretory pathway has been ambiguous. Previous studies of thermosensitive yeast...
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Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis.
Objective Bleeding ulcers and erosions are hallmarks of active ulcerative colitis (UC). However, the mechanisms controlling bleeding and mucosal haemostasis remain elusive. Design We used...
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Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53 mutant cells.
BACKGROUND: Chondrosarcomas are malignant cartilage-forming tumours of bone. Because of their resistance to conventional chemotherapy and radiotherapy, currently no treatment strategies exist for unresectable and...
Intranucleolar sites of ribosome biogenesis defined by the localization of early binding ribosomal proteins.
Considerable efforts are being undertaken to elucidate the processes of ribosome biogenesis. Although various preribosomal RNP complexes have been isolated and molecularly characterized, the order...
TRPM7 triggers Ca2+ sparks and invadosome formation in neuroblastoma cells.
Cell migration depends on the dynamic formation and turnover of cell adhesions and is tightly controlled by actomyosin contractility and local Ca2+ signals. The divalent...