Abstract
The logistic problem of B cell antigen encounter in the lymph node has recently been studied by dynamic imaging using two-photon microscopy. These studies combined with the early studies of antigen transport have yielded a more complete picture of the orchestration of B cell activation in vivo. Here we summarize the recent advances and focus on the specialized macrophages that are critical to this process and the role of B cells themselves as antigen transporting cells.
🔬 Techniques
✨ Fluorophores
🔬 Cell Lines
🏛️ Research Organizations (ROR)
Affiliated research institutions:
📊 Figures
Figure 1
Microanatomy of the lymph node
Schematic of a lymph node showing the locations for antigen presentation to B cells. 1) Subcapsular region. 2) Lymphoid follicle. 3) T zone (paracortex) in the vicinity of HEVs. Lymph drains in the af...
Figure 2
Dynamics of antigen capture in the lymph node
Schematic showing the fate of opsonized (irregular shape) and non-opsonized (circle) antigens draining in the afferent lymphatics. Within minutes SCS macrophages have sampled some of the opsonized ant...
Figure 3
Model for role of B cell antigen transport in the primary antibody response
Cognate B cells (green) acquire antigen from SCS macrophages (light brown) and migrate to the T-B border. Upon receipt of T cell help they differentiate into early plasmablasts and migrate to the medu...
Figure images are served from the NIH/NLM PubMed Central Open Access Subset or Europe PMC; copyright remains with the publishers and authors.
💬 Discussion
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