Organism • 46 papers
Metazoan RNA polymerase II is prone to pause in the promoter-proximal region of genes. This pausing involves DRB Sensitivity-Inducing Factor (DSIF) and Negative Elongation Factor...
Protein phosphorylation is a ubiquitous post-translational modification that regulates a plethora of intracellular processes, making its analysis crucial for understanding intracellular dynamics. The commonly used...
BACKGROUND: Cerebral white matter consists mainly of axons surrounded by myelin sheaths, which are grouped to form association, commissural, and projection fasciculi. The aim of...
The myosin holoenzyme is a multimeric protein complex consisting of heavy chains and light chains. Myosin light chains are calmodulin family members which are crucially...
Postreplicative maintenance of genomic methylation patterns was proposed to depend largely on the binding of DNA methyltransferase 1 (Dnmt1) to PCNA, a core component of...
ABSTRACT Pasteurella multocida is the leading cause of wound infections in humans following animals’ bites or scratches. This bacterium is also commonly found in the...
Succinate dehydrogenase (SDH) is a key fungicidal target, but rational inhibitors design has been impeded by the lack of fungal SDH structure. Here, we show...
Redox chemistry of quinones is an essential component of life on Earth. In the mitochondrial electron transport chain, the ubiquinone molecule is reduced to ubiquinol...
Malaria caused by Plasmodium falciparum remains a public health issue, yet direct targets of antimalarial drugs remain elusive. Membrane proteins in Plasmodium are potential drug...
Abstract The protein IWS1 (Interacts with SPT6 1) is implicated in transcription-associated processes, but a direct role in RNA polymerase (Pol) II function is unknown....