Abstract
The specific cellular role of mitochondria is influenced by the surrounding environment because effective mitochondrial function requires the delivery of inputs (e.g., oxygen) and export of products (e.g., signaling molecules) to and from other cellular components, respectively. Recent technological developments in mitochondrial imaging have led to a more precise and comprehensive understanding of the spatial relationships governing the function of this complex organelle, opening a new era of mitochondrial research. Here, I highlight current imaging approaches for visualizing mitochondrial form and function within complex cellular environments. Increasing clarity of mitochondrial behavior within cells will continue to lend mechanistic insights into the role of mitochondria under normal and pathological conditions and point to spatially regulated processes that can be targeted to improve cellular function.
🔬 Techniques
🔭 Microscopes
✨ Fluorophores
🧪 Sample Preparation
🔬 Cell Lines
🏛️ Research Organizations (ROR)
Affiliated research institutions:
📊 Figures
Figure 1:
Mitochondrial function relies on cellular interactions.
Depiction of a mitochondrion within a cell highlighting some of the many interactions with other cellular structures that can regulate acute mitochondrial function. Mitochondrial inputs are listed nex...
Figure 2:
Recent advances in mitochondrial imaging.
A) Fluorescent antibody labeled mitochondria (magenta) and lysosomes (yellow) within two layer V pyramidal neurons of the mouse somatosensory cortex visualized by expansion lattice light sheet microsc...
Figure images are served from the NIH/NLM PubMed Central Open Access Subset or Europe PMC; copyright remains with the publishers and authors.
💬 Discussion
0 commentsNo comments yet. Be the first to start a discussion!
Leave a Comment