Technique • 1935 papers
The VEGFR2 receptor tyrosine kinase regulates vascular physiology and animal development. The mechanism underlying VEGFR2 membrane trafficking is not well understood. Herein, we show that...
COPI coated vesicles carry material between Golgi compartments, but the role of COPI in the secretory pathway has been ambiguous. Previous studies of thermosensitive yeast...
The visualization of whole organs and organisms through tissue clearing and fluorescence volumetric imaging has revolutionized the way we look at biological samples. Its application to...
Technology developed in the past 10 years has dramatically increased the ability of researchers to directly visualize and measure various stages of the HIV type...
BACKGROUND: In plants, a complex cell wall protects cells and defines their shape. Cellulose fibrils form a multilayered network inside the cell-wall matrix that plays...
β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and desensitization. Despite recent structural advances, the mechanisms that govern receptor-β-arrestin interactions at the...
Two-dimensional Ti3C2T x MXenes exhibit exceptional electrical conductivity and tunable surface chemistry; however, reduction to zero-dimensional quantum dots (MQDs) affords quantum confinement and enriched functionalization,...
Diet can modulate cognitive aging, but the underlying mechanisms are poorly understood. Here, we show that specific lactic acid bacteria (LAB) ameliorate age-dependent decline of...
Abstract Coordinated cortical activity underlies voluntary movement planning, yet its disruption is implicated in neurodevelopmental disorders like autism spectrum disorder (ASD). Mutations in the SHANK3...
Abstract Spatial transcriptomics and in situ hybridisation techniques have become essential for contextualising single‐cell RNA sequencing (scRNA‐seq) data by mapping cell type– and state–specific mRNA...