N-SIM

N-SIM

Microscope • 58 papers

🔥 High Impact

Tetraspanin 4 stabilizes membrane swellings and facilitates their maturation into migrasomes.

Nature communications 2023 📊 87

AbstractMigrasomes are newly discovered cell organelles forming by local swelling of retraction fibers. The migrasome formation critically depends on tetraspanin proteins present in the retraction...

⭐ Foundational

A platform for brain-wide imaging and reconstruction of individual neurons.

eLife 2016 📊 389

The structure of axonal arbors controls how signals from individual neurons are routed within the mammalian brain. However, the arbors of very few long-range projection...

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Alterations of sarcoplasmic reticulum-mediated Ca2+ uptake in a model of premature ventricular contraction (PVC)-induced cardiomyopathy.

Molecular and cellular biochemistry 2023 📊 6

Premature ventricular contractions (PVCs) are the most frequent ventricular arrhythmias in the overall population. PVCs are known to acutely enhance contractility by the post-extrasystolic potentiation...

Three-photon excited fluorescence microscopy enables imaging of blood flow, neural structure and inflammatory response deep into mouse spinal cord in vivo.

bioRxiv : the preprint server for biology 2024 📊 6

Abstract Nonlinear optical microscopy enables non-invasive imaging in scattering samples with cellular resolution. The spinal cord connects the brain with the periphery and governs fundamental...

💾 Data

Assessment of Murine Colon Inflammation Using Intraluminal Fluorescence Lifetime Imaging.

Molecules (Basel, Switzerland) 2022 📊 6

Inflammatory bowel disease (IBD) is typically diagnosed by exclusion years after its onset. Current diagnostic methods are indirect, destructive, or target overt disease. Screening strategies...

Multi-modal sensing with integrated machine learning to differentiate specific leukocytes targeted by electrically sensitive hybrid particles.

Biosensors & bioelectronics 2023 📊 6

The growing need for personalized, accurate, and non-invasive diagnostic technology has resulted in significant advancements, from pushing current mechanistic limitations to innovative modality developments across...

Distinct chromatin signature of histone H3 variant H3.3 in human cells.

Nucleus (Austin, Tex.) 2014 📊 6

Actively transcribed regions of the genome have been found enriched for the histone H3 variant H3.3. This variant is incorporated into nucleosomes throughout the cell...

🔥 High Impact

Vimentin intermediate filaments and filamentous actin form unexpected interpenetrating networks that redefine the cell cortex.

Proceedings of the National Academy of Sciences of the United States of America 2022 📊 81

The cytoskeleton of eukaryotic cells is primarily composed of networks of filamentous proteins, F-actin, microtubules, and intermediate filaments. Interactions among the cytoskeletal components are important...

💾 Data 🏷️ 1 RRID
🔥 High Impact

Bright and stable monomeric green fluorescent protein derived from StayGold.

Nature methods 2024 📊 81

The high brightness and photostability of the green fluorescent protein StayGold make it a particularly attractive probe for long-term live-cell imaging; however, its dimeric nature...

Confocal Laser Scanning MicroscopyDeconvolution MicroscopyExpansion MicroscopyFluorescence MicroscopyLive Cell ImagingSpinning Disk Confocal MicroscopyStructured Illumination MicroscopyWidefield Fluorescence MicroscopyZ-Stack ImagingAxio ImagerCSU-W1LSM 980N-SIMNikon Ti2TiTi2Yokogawa CSU-W1 Spinning DiskZeiss Axio ImagerZeiss LSM 980Zeiss LSM 980 ConfocalCaenorhabditis elegansEscherichia coliNIS-ElementsZENZEN BlueCoumarinEdUEGFPFITCFusionRedGFPmCherrymClovermEGFPmKate2mNeonGreenmScarletmTagBFPRFPTRITCVenusCell CultureExpansion MicroscopyFixationLipofectionLive ImagingParaformaldehyde FixationTransfectionAfrican Green Monkey Kidney COS-7HeLa (Henrietta Lacks)Yokogawa CSU-W1 Spinning DiskZeiss LSM 980 ConfocalFijiImageJNIS-ElementsZENZEN BlueExcelPythonCASInstitute of Basic Medical Sciences of the Chinese Academy of Medical SciencesMcGovern Institute for Brain ResearchMiddle Tennessee State UniversityMoscow Institute of Physics and TechnologyNational Research CenterOvchinnikov Institute of Bioorganic ChemistryPeking UniversityRussian Academy of SciencesState UniversityWestlake Institute for Advanced StudyWestlake Laboratory of Life Sciences and BiomedicineWestlake UniversityAddgeneBD BiosciencesBio-RadGibcoInvitrogenMatTekNew England BiolabsQiagenSigma-AldrichTakara BioThermo Fisher ScientificHamamatsu Orca Flash 4.0Olympus sCMOSsCMOSSemrock sCMOS100x/1.5 NA oilZeiss 63x/1.4 NA oil525/50 bandpass535/40 bandpass535/50 bandpassLeica 405/40 bandpassLeica 450/40 bandpassLeica 480/40 bandpassNikon 470/40 bandpassNikon 525/50 bandpassSemrock 470/28 bandpass
💾 Data

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