Organism • 988 papers
Chromosome segregation during mitosis and meiosis relies on the spindle and the functions of numerous microtubule-associated proteins (MAPs). One of the best-studied spindle MAPs is...
The visualization of whole organs and organisms through tissue clearing and fluorescence volumetric imaging has revolutionized the way we look at biological samples. Its application to...
Metabolism is highly dynamic and intrinsically heterogeneous at the cellular level. Although fluorescence microscopy has been commonly used for single cell analysis, bulky fluorescent probes...
WNT4 is a secreted protein that plays a critical role in the regulation of cell fate and embryogenesis. Biallelic variants in WNT4 have been linked...
Correct focal positioning is essential for microscopy imaging of live moving subjects such as Caenorhabditis elegans. However, many methods can be too slow to perform...
ABSTRACT Early life stresses impact reproductive outcomes in many organisms. In response to crowding and starvation, Caenorhabditis elegans nematodes diapause as dauer larvae, in which...
Macroautophagy is essential for the long-term health of neurons and astrocytes in the central nervous system (CNS). The six mammalian ATG8 paralogs (LC3A/B/C and GABARAP/GABARAPL1/L2)...
Abstract Background Nematodes communicate via diverse sex pheromones, including long-range volatile signals, short-range chemical cues, and contact-dependent molecules. While the ascaroside family of small molecules...
Diet can modulate cognitive aging, but the underlying mechanisms are poorly understood. Here, we show that specific lactic acid bacteria (LAB) ameliorate age-dependent decline of...
Abstract Cryo-electron tomography (cryo-ET) has become a key technique for observing the three-dimensional structures of biomolecular complexes and organelles in cellular and tissue environments in...