Microscope • 171 papers
Objective/Background.— The goal of this study was to better understand the cellular mechanisms involved in proton stimulation of calcitonin gene‐related peptide (CGRP) secretion from cultured...
ABSTRACT Early life stresses impact reproductive outcomes in many organisms. In response to crowding and starvation, Caenorhabditis elegans nematodes diapause as dauer larvae, in which...
BubR1 is a key component of the mitotic checkpoint, a surveillance mechanism which ensures accurate chromosome segregation by facilitating the assembly of the mitotic checkpoint...
Kainate receptors (KARs) are critical mediators and modulators of synaptic transmission which undergo rapid activation and desensitization upon binding of the neurotransmitter glutamate. Under various...
Studying the function of healthy corneal endothelial cells has been challenging due to a variety of culturing strategies. Here, we present a standardized protocol for...
While blood vessels and osteocytes have been studied independently, their simultaneous changes with age remain undescribed. Our objective was to investigate the age-related evolution of...
Background: Although multiple functions of Cav1.3 in adult rat cochlea have been explored, its role in developing stria vascularis (SV) ofSprague–Dawley (SD) rats has rarely...
Here, we describe a strategy to analyze the exit of apical and basolateral cargo from the trans-Golgi network in primary hepatocytes. The method is based...
Abstract Tissue-clearing techniques have transformed optical imaging of fixed specimens, yet their application to living systems remains limited by toxicity and removal of key tissue...
Fluorescence lifetime imaging microscopy (FLIM) measures the average time that a fluorophore spends in the excited state. FLIM is exceptionally useful as an imaging tool...