Technique • 855 papers
The multi-scale organization of chromatin underlies gene regulation and cell identity, yet how nuclear architecture remodels during cell state transitions remains poorly understood. Here, we...
The mini Singlet Oxygen Generator (miniSOG) is a genetically encoded flavin-binding protein that enables photocatalytic proximity labeling upon blue-light illumination. Despite its widespread adoption for...
The last decade has witnessed significant advance in the imaging of living systems using fluorescent markers. This progress has been primarily associated with the discovery...
ABSTRACT Spectroscopic single‐molecule localization microscopy (sSMLM) simultaneously acquires both spatial and spectral information from fluorescent molecules, facilitating molecular characterization analysis and multicolor imaging. However, this...
ABSTRACT Super‐resolution microscopy with DNA‐fluorophore labels is primed for multi‐target imaging of cell biological samples. However, direct interaction with the sample is required to exchange...
ABSTRACT Simultaneous multiplexed super-resolution imaging remains a central challenge in single-molecule localization microscopy (SMLM), due to the limited number of spectrally distinguishable fluorophores and the...
Phosphoinositides make up only a small fraction of cellular phospholipids yet control cell function in a fundamental manner. Through protein interactions, phosphoinositides define cellular organelle...
ABSTRACT Biological research is in constant need of new methodological developments to assess organization and functions at various scales ranging from whole organisms to interactions...
It is challenging to understand viral proteins at a single-molecule level and visualize their dynamics in a cellular environment. This calls for sophisticated microscopy techniques...