Noncanonical autophagy at ER exit sites regulates procollagen turnover.
Type I collagen is the main component of bone matrix and other connective tissues. Rerouting of its procollagen precursor to a degradative pathway is crucial...
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Microscope • 112 papers
Complement activation in multiple sclerosis plaques: an immunohistochemical analysis.
INTRODUCTION: Inflammation and complement activation are firmly implicated in the pathology of multiple sclerosis; however, the extent and nature of their involvement in specific pathological...
EPHA2 is associated with age-related cortical cataract in mice and humans.
Age-related cataract is a major cause of blindness worldwide, and cortical cataract is the second most prevalent type of age-related cataract. Although a significant fraction...
Salmonella trafficking is defined by continuous dynamic interactions with the endolysosomal system.
Following invasion of non‐phagocytic host cells, Salmonella enterica survives and replicates within a phagosome‐like compartment known as the Salmonella ‐containing vacuole (SCV). It is now...
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Leader cells regulate collective cell migration via Rac activation in the downstream signaling of integrin β1 and PI3K.
Collective cell migration plays a crucial role in several biological processes, such as embryonic development, wound healing, and cancer metastasis. Here, we focused on collectively...
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Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor.
Evidence suggests that flavonoid-rich foods are capable of inducing improvements in memory and cognition in animals and humans. However, there is a lack of clarity...
Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy.
Mitophagy is thought to play an important role in mitochondrial quality control. Mitochondrial division is believed to occur first, and autophagosome formation subsequently occurs to...
Direct lysosome-based autophagy of lipid droplets in hepatocytes.
Hepatocytes metabolize energy-rich cytoplasmic lipid droplets (LDs) in the lysosome-directed process of autophagy. An organelle-selective form of this process (macrolipophagy) results in the engulfment of...
IFITM3 directly engages and shuttles incoming virus particles to lysosomes.
Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) have emerged as important innate immune effectors that prevent diverse virus infections in vertebrates. However, the cellular...
Overcoming endosomal barrier by amphotericin B-loaded dual pH-responsive PDMA-b-PDPA micelleplexes for siRNA delivery.
The endosomal barrier is a major bottleneck for the effective intracellular delivery of siRNA by nonviral nanocarriers. Here, we report a novel amphotericin B (AmB)-loaded,...