Axio Observer

Axio Observer

Microscope β€’ 62 papers

⭐ Foundational

Rapid movement and transcriptional re-localization of human cohesin on DNA.

The EMBO journal 2016 πŸ“Š 209

Abstract The spatial organization, correct expression, repair, and segregation of eukaryotic genomes depend on cohesin, ring‐shaped protein complexes that are thought to function by entrapping...

⭐ Foundational

Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels.

The Journal of experimental medicine 2009 πŸ“Š 296

Although both processes occur at similar rates, leukocyte extravasation from the blood circulation is well investigated, whereas intravasation into lymphatic vessels has hardly been studied....

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⭐ Foundational

Photoacoustic imaging of living mouse brain vasculature using hollow gold nanospheres.

Biomaterials 2010 πŸ“Š 301

Photoacoustic tomography (PAT) also referred to as optoacoustic tomography (OAT) is a hybrid imaging modality that employs nonionizing optical radiation and ultrasonic detection. Here, we...

⭐ Foundational

RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether.

Cell 2019 πŸ“Š 524

Long-distance RNA transport enables local protein synthesis at metabolically-active sites distant from the nucleus. This process ensures an appropriate spatial organization of proteins, vital to...

πŸ’Ύ Data 🏷️ 7 RRIDs
⭐ Foundational

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown.

Nature biotechnology 2015 πŸ“Š 604

A central hurdle in developing small interfering RNAs (siRNAs) as therapeutics is the inefficiency of their delivery across the plasma and endosomal membranes to the...

Therapeutic Modulation of Cell Morphology and Phenotype of Diseased Human Cells towards a Healthier Cell State Using Lignin.

Polymers 2023 πŸ“Š 6

Despite lignin's global abundance and its use in biomedical studies, our understanding of how lignin regulates disease through modulation of cell morphology and associated phenotype...

Cultured Vagal Afferent Neurons as Sensors for Intestinal Effector Molecules.

Biosensors 2023 πŸ“Š 6

The gut-brain axis embodies the bi-directional communication between the gastrointestinal tract and the central nervous system (CNS), where vagal afferent neurons (VANs) serve as sensors...

Participation of calcium-permeable AMPA receptors in the regulation of epileptiform activity of hippocampal neurons.

Frontiers in synaptic neuroscience 2024 πŸ“Š 6

INTRODUCTION: Epileptiform activity is the most striking result of hyperexcitation of a group of neurons that can occur in different brain regions and then spread...

Live Imaging of Shoot Meristems on an Inverted Confocal Microscope Using an Objective Lens Inverter Attachment.

Frontiers in plant science 2017 πŸ“Š 6

Live imaging of above ground meristems can lead to new insights in plant development not possible from static imaging of fixed tissue. The use of...

Polar localization of CheO under hypoxia promotes Campylobacter jejuni chemotactic behavior within host.

PLoS pathogens 2022 πŸ“Š 6

Campylobacter jejuni is a food-borne zoonotic pathogen of worldwide concern and the leading cause of bacterial diarrheal disease. In contrast to other enteric pathogens, C....

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