Axio Observer

Axio Observer

Microscope โ€ข 62 papers

๐Ÿ”ฅ High Impact

Nanoscale architecture of the Schizosaccharomyces pombe contractile ring.

eLife 2017 ๐Ÿ“Š 81

The contractile ring is a complex molecular apparatus which physically divides many eukaryotic cells. Despite knowledge of its protein composition, the molecular architecture of the...

๐Ÿ’พ Data
๐Ÿ”ฅ High Impact

Intelligent image-based in situ single-cell isolation.

Nature communications 2018 ๐Ÿ“Š 82

AbstractQuantifying heterogeneities within cell populations is important for many fields including cancer research and neurobiology; however, techniques to isolate individual cells are limited. Here, we...

๐Ÿ”ฅ High Impact

Posing for a picture: vesicle immobilization in agarose gel.

Scientific reports 2016 ๐Ÿ“Š 81

AbstractTaking a photo typically requires the object of interest to stand still. In science, imaging is potentiated by optical and electron microscopy. However, living and...

๐Ÿ”ฅ High Impact

Quantitative mapping of fluorescently tagged cellular proteins using FCS-calibrated four-dimensional imaging.

Nature protocols 2018 ๐Ÿ“Š 86

The ability to tag a protein at its endogenous locus with a fluorescent protein (FP) enables quantitative understanding of protein dynamics at the physiological level....

๐Ÿ“‹ 2 ๐Ÿ’พ Data
๐Ÿ”ฅ High Impact

Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer’s disease.

Nature neuroscience 2012 ๐Ÿ“Š 84

Experience-induced expression of immediate-early gene Arc (also known as Arg3.1) is known to be important for consolidation of memory. Using in vivo longitudinal multiphoton imaging,...

โญ Foundational

Luminal mitosis drives epithelial cell dispersal within the branching ureteric bud.

Developmental cell 2013 ๐Ÿ“Š 119

The ureteric bud is an epithelial tube that undergoes branching morphogenesis to form the renal collecting system. Although development of a normal kidney depends on...

๐Ÿ’พ Data
โญ Foundational

Portable lensless wide-field microscopy imaging platform based on digital inline holography and multi-frame pixel super-resolution.

Light, science & applications 2015 ๐Ÿ“Š 123

AbstractIn this paper, an irregular displacement-based lensless wide-field microscopy imaging platform is presented by combining digital in-line holography and computational pixel super-resolution using multi-frame processing....

โญ Foundational

Src-dependent phosphorylation of caveolin-1 Tyr-14 promotes swelling and release of caveolae.

Molecular biology of the cell 2016 ๐Ÿ“Š 122

Caveolin 1 (Cav1) is a required structural component of caveolae, and its phosphorylation by Src is associated with an increase in caveolae-mediated endocytosis. Here we...

โญ Foundational

Cohesin mediates DNA loop extrusion by a “swing and clamp” mechanism.

Cell 2021 ๐Ÿ“Š 129

Structural maintenance of chromosomes (SMC) complexes organize genome topology in all kingdoms of life and have been proposed to perform this function by DNA loop...

๐Ÿ’พ Data ๐Ÿท๏ธ 6 RRIDs
โญ Foundational

Live tracking of moving samples in confocal microscopy for vertically grown roots.

eLife 2017 ๐Ÿ“Š 125

Roots navigate through soil integrating environmental signals to orient their growth. The Arabidopsis root is a widely used model for developmental, physiological and cell biological...

๐Ÿ“‹ 22 ๐Ÿ’พ Data

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