Microscope • 236 papers
Animals with small nervous systems have a limited number of sensory neurons that must encode information from a changing environment. This problem is particularly exacerbated...
The glycocalyx of endothelial cells is a dynamic, gel-like layer of glycoproteins, proteoglycans, and glycolipids that lines the luminal surface of blood vessels, playing a...
ABSTRACT The spindle is a key structure in cell division as it orchestrates the accurate segregation of genetic material. While its assembly and function are...
Studies of human induced pluripotent stem cell (iPSC)-derived neurons promise important insights into neurodegenerative diseases. Here, we present a protocol for live imaging of axonal...
SUMMARY Chronic neuroinflammation in Alzheimer’s disease (AD) activates astrocytes—key regulators of both brain immunity and neurovascular coupling. The primed immune environment in AD brain also...
Persister cells are present at low frequency in isogenic populations. Moreover, they are only distinguishable from the bulk at the recovery time, after the antibiotic...
The transcriptional machinery of a cell is often not homogenously distributed but rather forms clusters in the nucleus. These clusters are important for gene expression,...
Predicting lithium-ion battery performance is hindered by microscale electrode heterogeneities invisible to conventional diagnostics. Here, we combine electrochemical fluorescence microscopy (EFM), which maps electronic connectivity...
Classical histology struggles to preserve three-dimensional spatial context, prompting the emergence of optical tissue clearing techniques that enable imaging of intact specimens at cellular or...
Polarized elongation in filamentous fungi depends on secretory vesicles being supplied and fusing at the apex. In Ascomycota and Basidiomycota, these vesicles have mostly been...