Leica STELLARIS 5

Leica STELLARIS 5

Microscope β€’ 24 papers

Protocol for supervised automation of cell counting in confocal microscopic mice cochlear imaging datasets using macro in Imaris.

STAR protocols 2025 πŸ“Š 1

Analyzing confocal microscopic data using Imaris is time-consuming and prone to human error. We present a supervised automation protocol to reduce manual input for cell...

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Structure-guided screening identifies Tucatinib as dual inhibitor for MCT1/2.

EMBO reports 2026 πŸ“Š 1

Abstract Cell surface glycoproteins Basigin or embigin form heterodimers with monocarboxylate transporters (MCTs), enhancing their membrane trafficking and modulating their transport functions. Cancer cells often...

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Preserving spatial and quantitative information in unpaired biomedical image-to-image translation.

Cell reports methods 2025 πŸ“Š 1

Analysis of biological samples often requires integrating diverse imaging modalities to gain a comprehensive understanding. While supervised biomedical image translation methods have shown success in...

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Polystyrene microplastics cross the murine intestine and induce inflammatory cell death after phagocytosis by human monocytes and neutrophils.

iScience 2025 πŸ“Š 3

Microplastics have been detected in human blood, raising concerns about human health. Here, we investigated the tissue distribution of microplastics after oral exposure in mice...

🏷️ 1 RRID

Targeting Cancer with Redox Catalysis: Manganese Porphyrins and Ascorbate Synergistically Induce Selective Oxidative Stress and Necrotic Cell Death.

Cancers 2025 πŸ“Š 1

BACKGROUND: The combination of manganese porphyrins (MnPs) and ascorbate (ASC) represents a promising redox-based therapeutic approach for selectively targeting cancer cells. We investigated the cytotoxic...

A novel method (RIM-Deep) for enhancing imaging depth and resolution stability of deep cleared tissue in inverted confocal microscopy.

eLife 2025

The increasing use of tissue clearing techniques underscores the urgent need for cost-effective and simplified deep imaging methods. While traditional inverted confocal microscopes excel in...

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Enkephalinergic Neurons in Barrington’s Nucleus Gate Sex-Specific Control of Micturition.

Research square 2025 πŸ“Š 1

Abstract Lower urinary tract (LUT) control is a vital physiological function governed by a complex interplay between neural circuits and muscle activity. This regulation depends...

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Lysionotin promoted apoptosis of hepatocellular carcinoma cells via inducing autophagy.

Discover oncology 2025 πŸ“Š 2

BACKGROUND: Hepatocellular carcinoma is a prevalent malignant tumor with a high mortality rate. Natural plants hold promise for its treatment, however, the mechanism of lysionotin...

Exploring Imaging Applications of a Red-Emitting Ο€-Acceptor (Ο€-A) Pyrene-Benzothiazolium Dye.

Biosensors 2024 πŸ“Š 2

Bright biocompatible fluorescent imaging dyes with red to near-infrared (NIR) emissions are ideal candidates for fluorescence microscopy applications. Pyrene-benzothiazolium hemicyanine dyes are a new class...

The impact of macrophage phenotype and heterogeneity on the total internalized gold nanoparticle counts.

Nanoscale advances 2024 πŸ“Š 2

Macrophages play a pivotal role in the internalization and processing of administered nanoparticles (NPs). Furthermore, the phagocytic capacity and immunological properties of macrophages can vary...

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