Microscope β’ 22 papers
Norepinephrine (NE), a neuromodulator released by locus ceruleus (LC) neurons throughout the cortex, influences arousal and learning through extrasynaptic vesicle exocytosis. While NE within cortical...
INTRODUCTION: The morphological and molecular changes associated with the degeneration of arterioles in cerebral amyloid angiopathy (CAA) are incompletely understood. METHODS: Post mortem brains from...
Psilocybin, ketamine, and MDMA are psychoactive compounds that exert behavioral effects with distinguishable but also overlapping features. The growing interest in using these compounds as...
Transsynaptic viral tracing requires tissue sectioning, manual cell counting, and anatomical assignment, all of which are time intensive. We describe a protocol for BrainPipe, a...
Abstract Maintaining body temperature is calorically expensive for endothermic animals 1 . Mammals eat more in the cold to compensate for energy expenditure 2 ,...
Abstract Addiction prioritizes drug use over innate needs by βhijackingβ brain circuits that direct motivation, but how this develops remains unclear. Using whole-brain FOS mapping...
Abstract 3D standard reference brains serve as key resources to understand the spatial organization of the brain and promote interoperability across different studies. However, unlike...
Abstract Aging is the largest risk factor for neurodegenerative disorders, and commonly associated with compromised cerebrovasculature and pericytes. However, we do not know how normal...
Drugs of abuse are thought to promote addiction in part by βhijackingβ brain reward systems, but the underlying mechanisms remain undefined. Using whole-brain FOS mapping...
Abstract Aging is frequently associated with compromised cerebrovasculature and pericytes. However, we do not know how normal aging differentially impacts vascular structure and function in...