Microscope โข 22 papers
AbstractVisceral sensory pathways mediate homeostatic reflexes, the dysfunction of which leads to many neurological disorders1. The BezoldโJarisch reflex (BJR), first described2,3 in 1867, is a...
Glioblastomas (GBMs) functionally integrate into diverse neuronal circuits within the central nervous system, which can promote tumor progression and affect neurons via neuron-to-glioma synapses. It...
Whole-brain clearing and imaging methods are becoming more common in mice but have yet to become standard in rats, at least partially due to inadequate...
Abstract Revealing how individual axons create a brain-wide connectome would be indispensable for understanding brain function and behavior, yet remains technically challenging. We introduce MAPL3,...
Rett syndrome (RTT) is a neurodevelopmental disorder that is caused by loss-of-function mutations in the methyl-CpG binding protein 2 (MeCP2) gene. RTT patients experience a...
Abstract Light-sheet microscopy has made possible the 3D imaging of both fixed and live biological tissue, with samples as large as the entire mouse brain....
Abstract Recent advances in 3D pathology offer the ability to image orders-of-magnitude more tissue than conventional pathology while providing a volumetric context that is lacking...
Male ejaculation acutely suppresses sexual motivation in male mice. In contrast, relatively little is known about how male ejaculation affects sexual motivation and sexual behavior...
Abstract Microvascular insulin delivery to myocytes is rate limiting for the onset of insulin-stimulated muscle glucose uptake. The structural integrity of capillaries of the microvasculature...
Abstract Cerebral amyloid angiopathy (CAA) is a vasculopathy characterized by vascular ฮฒ-amyloid (Aฮฒ) deposition on cerebral blood vessels. CAA is closely linked to Alzheimerโs disease...