N-STORM

N-STORM

Microscope • 43 papers

🔥 High Impact

Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains.

Nature communications 2017 📊 83

Dopamine regulates reward, cognition, and locomotor functions. By mediating rapid reuptake of extracellular dopamine, the dopamine transporter is critical for spatiotemporal control of dopaminergic neurotransmission....

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🔥 High Impact

In Situ Super-Resolution Imaging of Genomic DNA with OligoSTORM and OligoDNA-PAINT.

Methods in molecular biology (Clifton, N.J.) 2017 📊 88

OligoSTORM and OligoDNA-PAINT meld the Oligopaint technology for fluorescent in situ hybridization (FISH) with, respectively, Stochastic Optical Reconstruction Microscopy (STORM) and DNA-based Point Accumulation for...

⭐ Foundational

Ultrastructure of the axonal periodic scaffold reveals a braid-like organization of actin rings.

Nature communications 2019 📊 126

Abstract Recent super-resolution microscopy studies have unveiled a periodic scaffold of actin rings regularly spaced by spectrins under the plasma membrane of axons. However, ultrastructural...

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⭐ Foundational

Super-resolution microscopy reveals how histone tail acetylation affects DNA compaction within nucleosomes in vivo.

Nucleic acids research 2019 📊 130

Abstract Chromatin organization is crucial for regulating gene expression. Previously, we showed that nucleosomes form groups, termed clutches. Clutch size correlated with the pluripotency grade...

⭐ Foundational

Super-resolution microscopy reveals structural diversity in molecular exchange among peptide amphiphile nanofibres.

Nature communications 2016 📊 129

AbstractThe dynamic behaviour of supramolecular systems is an important dimension of their potential functions. Here, we report on the use of stochastic optical reconstruction microscopy...

⭐ Foundational

Correlative super-resolution fluorescence and metal-replica transmission electron microscopy.

Nature methods 2014 📊 130

We combine super-resolution localization fluorescence microscopy with transmission electron microscopy of metal replicas to locate proteins on the landscape of the cellular plasma membrane at...

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⭐ Foundational

Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms.

Acta neuropathologica 2018 📊 138

Neurotropic herpesviruses can establish lifelong infection in humans and contribute to severe diseases including encephalitis and neurodegeneration. However, the mechanisms through which the brain's immune...

⭐ Foundational

Single-particle reconstruction of biological macromolecules in electron microscopy–30 years.

Quarterly reviews of biophysics 2009 📊 139

AbstractThis essay gives the autho's personal account on the development of concepts underlying single-particle reconstruction, a technique in electron microscopy of macromolecular assemblies with a...

⭐ Foundational

Real-time analysis and visualization for single-molecule based super-resolution microscopy.

PloS one 2013 📊 141

Accurate multidimensional localization of isolated fluorescent emitters is a time consuming process in single-molecule based super-resolution microscopy. We demonstrate a functional method for real-time reconstruction...

⭐ Foundational

Orchestration of DNA Damage Checkpoint Dynamics across the Human Cell Cycle.

Cell systems 2017 📊 155

Although molecular mechanisms that prompt cell-cycle arrest in response to DNA damage have been elucidated, the systems-level properties of DNA damage checkpoints are not understood....

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