Technique • 85 papers
Alzheimer's disease (AD) is a neurodegenerative disorder with synaptic pathology as a core theme in aging-related research. Conventional imaging and limited tools fail to resolve...
Analysing organelle structures in tissue samples that preserve the in vivo environment, rather than in isolated cells, can provide valuable information on the mechanisms underlying...
The misfolding and aberrant aggregation of alpha-synuclein (α-syn) constitute the central pathological hallmark of a spectrum of synucleinopathies, including Parkinson's disease, dementia with Lewy bodies,...
INTRODUCTION: The use of antimalarial chloroquine in malaria-endemic regions of Africa is rampant and it is not uncommon to find individuals taken the drug concurrent...
Aneuploidy, a cancer hallmark, drives chromosomal instability, drug resistance, and clinically aggressive tumors. Cyclin-dependent kinase 2 (CDK2) antagonism with independent inhibitors or CDK2 knockdown triggered...
Here, we present a protocol for generating postmortem human brain tissue samples suitable for volume electron microscopy (vEM) imaging via focused ion beam-scanning electron microscopy...
ABSTRACT Dendritic morphology is a defining characteristic of neuronal subtypes. In Drosophila , heterotypic olfactory receptor neurons (ORNs) expressing different receptors display diverse dendritic morphologies,...
Abstract Secondary metabolites are key mediators of bacterial environmental fitness and the primary source of antibiotics and other natural products. Despite intensive study in natural...
Abstract Background and Aims During the analysis of plant male meiocytes coming from destroyed meiocyte columns (united multicellular structures formed by male meiocytes in each...
To enable nervous system function, neurons are powered in a use-dependent manner by mitochondria undergoing morphological-functional adaptation. In a well-studied model system-the mammalian cochlea, auditory...