Technique • 360 papers
Analysing organelle structures in tissue samples that preserve the in vivo environment, rather than in isolated cells, can provide valuable information on the mechanisms underlying...
Abstract Alzheimer disease (AD), first described by Alzheimer and Perusini in the early twentieth century, is a devastating neurodegenerative disorder without a definitive cure. Unraveling...
Bovine trophoblast giant cells (TGC) are continuously formed and migrate towards the uterine epithelium (ME) to fuse with ME cells. To date it is not...
Correlative microscopy integrates complementary imaging modalities to enable structural analysis of biological samples across multiple length scales. Here, we present two correlative workflows for formalin-fixed,...
BACKGROUND: As cells that constantly survey their environment, microglia rely on contact with neurons, non-neuronal cells and extracellular substances. The diversity of microglial receptors allows...
Mitotic chromosome formation depends on coordinated SMC complex activities, yet how condensin engages cohesin during this process remains unclear. Samejima et al. combined synchronized mitotic entry,...
We here present the results of the first materials science analyses obtained with the prototype of a serial block-face sectioning and imaging tool, 3Viewtrade mark...
One of the major drawbacks in transmission electron microscopy has been the production of three-dimensional views of cells and tissues. Currently, there is no one...
A variety of methods for the investigation and 3D representation of the inner structure of materials has been developed. In this paper, techniques based on...
Mycobacterium tuberculosis modulation of macrophage cell death is a well-documented phenomenon, but its role during bacterial replication is less characterized. In this study, we investigate...