UltraMicroscope Microscopy Papers – Page 2

Spiner, deep learning-based automated detection of spiral ganglion neurons in intact cochleae.

iScience 2025 📊 1

Tissue clearing and light-sheet fluorescence microscopy were applied for 3D profiling of intact cochleae. However, the spiral ganglion neurons (SGNs) remain relatively understudied compared to...

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A multiscale vascular atlas of blood vessels supplying the urinary bladder of male and female mice.

American journal of physiology. Renal physiology 2025 📊 1

The vascular supply of the urinary bladder is embedded within a highly dynamic environment that includes alternating cycles of regional compression or stretching during bladder...

🏷️ 1 RRID

Insulin deficiency inhibits vaccine-mediated antibody and germinal center B-cell formation in mice.

bioRxiv : the preprint server for biology 2025

ABSTRACT Individuals with diabetes are at increased risk for severe outcomes from vaccine-preventable infections and often mount weaker immune responses to vaccination. The diabetes-related factors...

🏷️ 1 RRID

Temporal effects of sympathetic denervation on aortic remodeling and rupture in experimental abdominal aortic aneurysm.

American journal of physiology. Heart and circulatory physiology 2025

Abdominal aortic aneurysm (AAA) is a life-threatening condition with no effective pharmacologic therapies, and increasing evidence suggests that the sympathetic nervous system (SNS) contributes to...

Brightfield Microscopy Deconvolution Microscopy Fluorescence Microscopy Light Sheet Fluorescence Microscopy UltraMicroscope Hoechst 33342 Antigen Retrieval Fixation Hematoxylin and Eosin Immunohistochemistry Permeabilization Tissue Clearing Primary Macrophages UltraMicroscope Imaris Northwestern University University Feinberg School of Medicine University McCormick School of Engineering

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Oxidation-reduction imaging of myoglobin reveals two-phase oxidation in the reperfused myocardium.

Basic research in cardiology 2024 📊 1

AbstractMyocardial infarction (MI) is a serious acute cardiovascular syndrome that causes myocardial injury due to blood flow obstruction to a specific myocardial area. Under ischemic–reperfusion...

Confocal Laser Scanning Microscopy Fluorescence Microscopy Light Sheet Fluorescence Microscopy UltraMicroscope Knockout Tissue Clearing UltraMicroscope Amira CNRS INSERM Institut Pasteur Lebanese University Université Claude Bernard Lyon 1 SPAD

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Enkephalinergic Neurons in Barrington’s Nucleus Gate Sex-Specific Control of Micturition.

Research square 2025 📊 1

Abstract Lower urinary tract (LUT) control is a vital physiological function governed by a complex interplay between neural circuits and muscle activity. This regulation depends...

Calcium Imaging Confocal Laser Scanning Microscopy Light Sheet Fluorescence Microscopy Optogenetics Z-Stack Imaging Leica Stellaris Leica STELLARIS 5 Olympus BX63 UltraMicroscope cellSens LAS X OlyVIA Alexa Fluor 594 Alexa Fluor 647 DAPI DiO DsRed EGFP GCaMP GCaMP6s GFP mCherry tdTomato Adeno-Associated Virus Blocking Clustered Regularly Interspaced Short Palindromic Repeats Fixation Immunohistochemistry Immunolabeling-enabled Three-Dimensional Imaging of Solvent-Cleared Organs Microtome Paraformaldehyde Fixation Permeabilization RNAscope Tissue Clearing Transduction Whole Mount Primary Oligodendrocytes Leica Stellaris Leica STELLARIS 5 Olympus BX63 UltraMicroscope ImageJ Imaris cellSens LAS X OlyVIA MATLAB R Beth Israel Deaconess Medical Center and Harvard Medical School Harvard Medical School Massachusetts Eye and Ear Infirmary and Harvard Medical School University of Maryland School of Medicine Addgene Jackson ImmunoResearch Millipore Sigma-Aldrich Thermo Fisher Scientific Chicken Donkey Rabbit

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An anatomically informed computational fluid dynamics modeling approach for quantifying hemodynamics in the developing heart.

PloS one 2025 📊 1

Congenital heart defects occur in approximately 1% of newborns in the US annually. Currently, less than a third of congenital heart defects can be traced...

Fluorescence Microscopy Light Sheet Fluorescence Microscopy UltraMicroscope DiD Fixation Immunolabeling-enabled Three-Dimensional Imaging of Solvent-Cleared Organs Paraformaldehyde Fixation Primary Endothelial Cells UltraMicroscope Imaris inForm R University North Carolina University of North Carolina University of North Carolina at Chapel Hill University of North Carolina at Chapel Hill School of Medicine

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ClearFinder: a Python GUI for annotating cells in cleared mouse brain.

BMC bioinformatics 2025

Abstract Background Tissue clearing combined with light-sheet microscopy is gaining popularity among neuroscientists interested in unbiased assessment of their samples in 3D volume. However, the...

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Quantitative profiling of whole-brain connectomes at single-axon resolution using deep learning and high-resolution light sheet microscopy.

bioRxiv : the preprint server for biology 2025

Abstract Revealing how individual axons create a brain-wide connectome would be indispensable for understanding brain function and behavior, yet remains technically challenging. We introduce MAPL3,...

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Protocol for rapid 5-plex 3D imaging and single-cell analysis of immune responses in whole murine lymph nodes.

STAR protocols 2025

Lymph nodes orchestrate adaptive immune responses, with germinal centers enabling affinity maturation and plasma cell formation. Here, we present a protocol for rapid, high-resolution, multicolor...

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