Bioimaging with Upconversion Nanoparticles.
Bioimaging enables the spatiotemporal visualization of biological processes at various scales empowered by a range of different imaging modalities and contrast agents. Upconversion nanoparticles (UCNPs)...
N-SIM
N-SIM
Microscope • 58 papers
Cross-modal coherent registration of whole mouse brains.
Recent whole-brain mapping projects are collecting large-scale three-dimensional images using modalities such as serial two-photon tomography, fluorescence micro-optical sectioning tomography, light-sheet fluorescence microscopy, volumetric imaging...
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Visualizing Mitochondrial Form and Function within the Cell.
The specific cellular role of mitochondria is influenced by the surrounding environment because effective mitochondrial function requires the delivery of inputs (e.g., oxygen) and export...
Desmosome assembly and disassembly are membrane raft-dependent.
Strong intercellular adhesion is critical for tissues that experience mechanical stress, such as the skin and heart. Desmosomes provide adhesive strength to tissues by anchoring...
An arbitrary-spectrum spatial visual stimulator for vision research.
Visual neuroscientists require accurate control of visual stimulation. However, few stimulator solutions simultaneously offer high spatio-temporal resolution and free control over the spectra of the...
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Cortical Representations of Conspecific Sex Shape Social Behavior.
A central question related to virtually all social decisions is how animals integrate sex-specific cues from conspecifics. Using microendoscopic calcium imaging in mice, we find...
Electrophysiology, Unplugged: Imaging Membrane Potential with Fluorescent Indicators.
Membrane potential is a fundamental biophysical property maintained by every cell on earth. In specialized cells like neurons, rapid changes in membrane potential drive the...
Microtubule-dependent transport and dynamics of vimentin intermediate filaments.
We studied two aspects of vimentin intermediate filament dynamics-transport of filaments and subunit exchange. We observed transport of long filaments in the periphery of cells...
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The telomere bouquet is a hub where meiotic double-strand breaks, synapsis, and stable homolog juxtaposition are coordinated in the zebrafish, Danio rerio.
Meiosis is a cellular program that generates haploid gametes for sexual reproduction. While chromosome events that contribute to reducing ploidy (homologous chromosome pairing, synapsis, and...
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Widespread and Highly Correlated Somato-dendritic Activity in Cortical Layer 5 Neurons.
Dendritic integration can expand the information-processing capabilities of neurons. However, the recruitment of active dendritic processing in vivo and its relationship to somatic activity remain poorly...